Brief Reports Role of the MMP9 Gene in Hemorrhagic Transformations After Tissue-Type Plasminogen Activator Treatment in Stroke Patients

نویسندگان

  • Israel Fernández-Cadenas
  • Anna Rosell
  • Manolo Quintana
  • Jordi Jiménez-Conde
چکیده

Israel Fernández-Cadenas, PhD*; Alberto del Río-Espínola, PhD*; Caty Carrera, MSc*; Sophie Domingues-Montanari, PhD; Maite Mendióroz, MD, PhD; Pilar Delgado, MD, PhD; Anna Rosell, PhD; Marc Ribó, MD, PhD; Dolors Giralt, MSc; Manolo Quintana, MSc; Mar Castellanos, MD, PhD; Victor Obach, MD, PhD; Sergi Martínez, MD, PhD; Mari Mar Freijo, MD; Jordi Jiménez-Conde, MD, PhD; Jaume Roquer, MD, PhD; Joan Martí-Fábregas, MD, PhD; Carlos A. Molina, MD, PhD; José Álvarez-Sabín, MD, PhD; Joan Montaner, MD, PhD

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Role of the MMP9 gene in hemorrhagic transformations after tissue-type plasminogen activator treatment in stroke patients.

BACKGROUND AND PURPOSE Despite the benefits of tissue-type plasminogen activator treatment, some stroke patients experience adverse hemorrhagic transformations (HT). Plasma protein levels of MMP9 have been associated with HT occurrence. We aimed to analyze the association of the MMP9 gene with HT occurrence. METHODS We analyzed the MMP9 gene in blood samples from 885 stroke patients treated w...

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تاریخ انتشار 2012